As a result, if you try to set Alfred's hotkey to Cmd + Space, you may find that you can't immediately to do so. If you're unable to set it by simply highlighting the Alfred Hotkey field and typing your combo, the combination may be: Type your key combo (ctrl, alt and/or cmd + space/character) to set it.
To set your hotkey, go to the Alfred preferences and view the General tab. Setting your Alfred hotkey to Cmd + Space or any other combination As it's a desirable one, you'll need to disable interfering features in macOS before it can be used as your Alfred hotkey.
Cmd + Space is a very convenient hotkey combination you may want to use for Alfred.